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Jeenomics, the NGS Laboratory is recognised by DSIR (Department of Science and Technology, Government of India) as SIRO and has a dedicated team of scientists involved in meaningful research that, in future can shape the way the patients are treated. Find below some of the recent publications and research work in progress.

List of Publications/Submissions (2014-2020)

  • Martin Maiers, Michael Halagan, Sangeeta Joshi, H Sudarshan Ballal, LathaJagannatthan, SharatDamodar, Periathiruvadi Srinivasan,Saranya Narayan, NavinKhattry, Pankaj Malhotra, Ranjana W Minz, Sandip A Shah, Raghu Rajagopal, NezihCereb, Soo Young Yang,Sunil Parekh, Joy Mammen, Dolly Daniels, Daniel Weisdorf. HLA match likelihoods for Indian patients seeking unrelated donor transplantation grafts: a population-based studyLancet Haematol. 2014.1(2):e57-63. doi: 10.1016/S2352-3026(14)70021-3. Epub 2014 Oct 21.
  • • Vikram Haridas, Praveenkumar Shetty, M Nirmal Kumar, KC Vasanthakumar, Kiran Haridas, VitthalKhode, Anil Bargale. Human leukocyte Antigen-B*27 allele subtype prevalence and disease association of ankylosing spondylitis among south Indian population. Indian Journal of Rheumatology. 2018.13(1):38-43.
  • Srinivasan P. Urgent need for a South Asian Hematopoietic stem cell donor registry. Global J Transfus Med. 2018. 3:56-58
  • Seshasubramanian Vani, Manisekar Nirmal Kumar, SathishkannanAruna Devi, NaganathanChandramouleeswaran and Narayan Saranya. Next Generation Sequencing in HLA Haplotype distribution among Telugu Speaking Population from South India. Human Immunology. 2018. 79(8):583-584. https://doi.org/10.1016/j.humimm.2018.05.005.
  • Vani Seshasubramanian, Nirmal Kumar Manisekar, Aruna Devi Sathishkannan, ChandramouleeswaranNaganathan, Yogesh Nandakumar and Saranya Narayan. Urdu Speaking Population from South India. 6 extended haplotypes in linkage disequilibrium in Urdu Speaking Population of South India. HLA. 2018. 92:266-268. doi: 10.1111/tan.13326.
  • Vani Seshasubramanian, Nirmal Kumar Manisekar, Aruna Devi Sathishkannan, ChandramouleeswaranNaganathan, Yogesh Nandakumar and Saranya Narayan. Kannadigas from South India: Extended haplotypes in Linkage disequilibrium in Kannadigas of South India. HLA.2018. 92:193-195. doi: 10.1111/tan.13324.
  • • Saranya Narayan; Martin Maiers; Mike Halagan; ArunadeviSathishkannan; ChandramouleeswaranNaganathan; AbeerMadbouly. HLA-A, -B, -C, -DRB1 and –DQB1 haplotype frequencies from 2492 Cord Blood Units from Tamil speaking population from Tamil Nadu, India. Molecular Biology reports.2018. https://doi.org/10.1007/s11033-018-4382-6.
  • • Vani Seshasubramanian, Nirmal Kumar Manisekar, Aruna Devi Sathishkannan, ChandramouleeswaranNaganathan, Yogesh Nandakumar, Saranya Narayan.Malayalam speaking population from South India: Common five-locus haplotypes in Malayalam speaking population.HLA.2018. 92:432-434. doi: 10.1111/tan.13389.
  • Aarthi Manoharan, Ajay Sam Kumar, AmbujamSreedevi, Aruna Devi Sathishkannan, Bhargav Kiran Gaddam. HLA-B*5701 and HLA-B*5801 in an Indian patient with anti-epileptics induced cutaneous adverse drug reactions. European Journal of Clinical Pharmacology. 2018. 75:599-601. https://doi.org/10.1007/s00228-018-02618-5
  • Vani Seshasubramanian, Aruna Devi SatishKannan, Chandramouleeswaran Naganathan, Nirmal Kumar Manisekar, Saranya Narayan. Identification of the novel HLA allele, HLA‐B*35:03:23, by next‐generation sequencing. HLA. 2019. 93(2-3):112-113. https://doi.org/10.1111/tan.13459
  • Vani Seshasubramanian, Aruna Devi Satish Kannan, Chandramouleeswaran Naganathan, Yogesh NandakumarSaranya Narayan. Identification of the novel Allele, HLA‐B*40:379, by next‐generation sequencing.. HLA. 2019. 93(2-3):117-119 https://doi.org/10.1111/tan.13460.
  • Vani,S., Meganathan,V., Nirmal Kumar,M., ArunaDevi,S., Chandramouleeswaran,N., Yogesh,N., Saranya,N. and Srinivasan,P. Application of high throughput Next Generation Sequencing for HLA typing of DNA extracted from post processing cord blood units. HLA. 2019. 94 (2)141–146. https://doi.org/10.1111/tan.13565
  • Vani S, VijayaRaghavan, Aruna Devi S, Chandramouleeswaran N, Aparna R, Priya A, Preeti R, Sujit J, Brian M, Thara R, Saranya N, Srinivasan P. Association of HLA-A, -B, -C, -DRB1, and -DQB1 alleles and haplotypes with schizophrenia: A study from South India. International Journal of Immunogenetics

Novel HLA sequences submitted:

Gen bank No. WHO (IMGT Nomenclature) IMGT Assigned Date
MH192364 B*40:379 30 Jul 2018
MH192365 B*35:03:23 30 Jul 2018
MK854808 DQB1*02:156 30 May 2019
MK854809 B*35:455 30 May 2019
MN031261 B*13:129 31 Jul 2019
MN056825 DRB1*13:288 31 Jul 2019
MN067531 DQB1*06:359 30 Sep 2019
MN337293 B*38:02:08 30 Sep 2019
MN337294 C*07:837 30 Sep 2019
MN337295 DQB1*04:77 30 Sep 2019
MN337296 C*12:304 30 Sep 2019
MN337297 DQB1*06:142 30 Sep 2019
MN567304 B*52:01:48 30 Nov 2019
MN565841 B*58:121 31 Dec 2019
MN565840 C*14:02:29 31 Dec 2019
MN565839 A*01:291 30 Nov 2019
MN565839 A*01:291 30 Nov 2019
MN565838 Submitted
MN565837 C*15:215 31 Mar 2020
MN565836 Submitted
MN567302 A*03:360 30 Nov 2019
MN565835 Submitted
MN565834 DQB1*05:01:40 31 Mar 2020
MN565833 A*11:363 31 Mar 2020
MN567303 B*52:95 31 Dec 2019
MT043141 B*13:141 29 Feb 2020
MT043147 B*38:167 29 Feb 2020
MT043140 A*32:141 29 Feb 2020
MT043148 C*12:03:29 29 Feb 2020
MT043142 Submitted
MT043150 Submitted
MT043143 B*35:478 29 Feb 2020
MT043150 Submitted
MT043144 B*57:132 31 Mar 2020
MT043145 B*50:01:16 31 Mar 2020
MT043146 B*37:22:02 31 Mar 2020
MT043149 Submitted